- Ambassador: Rebecca E. Gonzales
- Deputy Chief of Mission: Daniel Katz
- Political/Economic Officer: Joshua Rodd
- Public Affairs Officer: Melissa Schumi Jones
- Management Officer: Jacob Rocca
- Information Management Officer: Michelle Judy
- General Services Officer: Lindsey Fair
- Regional Security Officer: Dennis Jones
- Consular Officer: Amanda Grier
- Center for Disease Control Director: Andy Pelletier
- PEPFAR Coordinator: Aubrey Casey
- USAID PEPFAR Lesotho Program Director: Kristen E. Ruckstuhl